Upstate South Carolina is defined by area code 864, created in 1995 and covering Greenville, Spartanburg, and Anderson. Nestled in the foothills of the Blue Ridge Mountains, the region is a hub of manufacturing, education, and revitalized downtowns. With a growing economy and Southern charm, it’s one of the state’s most dynamic zones. 864 reflects the energy and elegance of South Carolina’s Upstate region.